diff --git a/setup.py b/setup.py
index 8a2f7ea..1a33ea5 100644
--- a/setup.py
+++ b/setup.py
@@ -132,6 +132,7 @@ if __name__ == "__main__":
         # Required for SQLCipher.
         ("SQLITE_HAS_CODEC", "1"),
         ("SQLITE_TEMP_STORE", "2"),
+        ("SQLITE_THREADSAFE", "1")
         ("SQLITE_EXTRA_INIT", "sqlcipher_extra_init"),
         ("SQLITE_EXTRA_SHUTDOWN", "sqlcipher_extra_shutdown"),
         # Increase the maximum number of "host parameters".